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Disappearing Hyperdense Middle Cerebral Artery Sign in Ischaemic Stroke Patients Treated with Intravenous Thrombolysis: Clinical Course and Prognostic Significance JNNP 80:273-278,248, Kharitonova,T.,et al, 2009 See this aricle in Pubmed Article Abstract HMCAS disappeared after intravenous thrombolysis in about half of cases and these patients had twice as good outcomes compared with those with persistent HMCAS. The prognosis in patients with MCA occlusion that persists after intravenous thrombolysis is poor, which may indicate the need for an alternative treatment approach to this subgroup.

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